Industrial Biotechnology Research Group

RESEARCH GROUP
• Prof. Dr. Güzide ÇALIK
• Prof. Dr. Tuncer ÖZDAMAR

PhD and MS Students
Graduate students

RESEARCH AREA
Within the context of biochemical and chemical reaction engineering;
• Recombinant enzyme production
• Recombinant therapeutic protein production
• Rekombinant amino acid production
• Metabolik pathway engineering
• Reactor engineering

CURRENT PhD and MS STUDIES
Graduate studies leading to PhD and MSc degrees are carried out within the context of the projects mentioned above

SELECTED PUBLICATIONS
• Çalık, G., Savaşçı, H., Çalık, P., and Özdamar, T.H., 1999. Growth and K-Carrageenan Immobilisation of Pseudomonas dacunhae for L-Alanine Production, Enzyme and Microbial Technology . 24, 67-74.
• Çalık, P., Çalık, G., Takaç, S., and Özdamar, T.H., 1999. Metabolic Pathway Analysis for Serine Alkaline Protease Fermentation by Bacillus licheniformis in a defined medium: Effects of the oxygen Transfer Rate, Biotechnology & Bioengineering, 64(2), 151-167.
Çalık, P., and Özdamar, T.H., 1999. Mass Flux Balance-Based Model and Metabolic Pathway Analysis for Serine Alkaline Protease Synthesis by Bacillus licheniformis, Enzyme and Microbial Technology, 24(10), 621-635.
• Çalık, P., Takaç, S., Çalık, G., Özdamar,T.H., 2000. Serine Alkaline Protease Overproduction Capacity of Bacillus licheniformis , Enzyme and Microbiol Technology, 26(1), 45-60.
Çalık, P., Çalık, G., Özdamar,T.H ., 2000. Oxygen Transfer Strategy and its Regulation Effects in Serine Alkaline Protease Production by Bacillus licheniformis , Biotechnology & Bioengineering 69(3) , 301-311.
• Çalık, P., Çalık, G., Takaç, S., Özdamar,T.H., 2000. Metabolic Flux Analysis for Serine Alkaline Protease Production , Enzyme and Microbial Technology, 27(10), 793-805.
Çalık, P., and Özdamar, T.H , 2001. Carbon sources affect metabolic capacities of Bacillus species for the production of industrial enzymes : theoretical analyses for serine and neutral proteases and ?-amylase, Biochemical Engineering Journal , 8(1), 61-81.
Çalık, P., Çalık, G., Özdamar,T.H, 2001. Bioprocess Development for Serine Alkaline Protease Production, Reviews in Chemical Engineering, 17, Suppl. 1-62.
Çalık, G.,Ünlütabak, F., Özdamar, T.H., 2001. Product and By-product distribution in glutamic acid fermentation by Brevibacterium flavum : Effects of the oxygen transfer, Biochemical Engineering Journal, 9 , 91-101 .
Çalık, P., and Özdamar, T.H., 2002. Metabolic Flux Analysis for Therapeutic Protein Productions and Hypothesis to New Therapeutic Strategies in Medicine, Biochemical Engineering Journal, 11(1), 49-68.
Çalık, P., and Özdamar, T.H., 2002. Metabolic Flux Analysis for industrial microorganisms: A review, Reviews in Chemical Engineering, 18(6), 553-596.
Çalık, P., Bilir, E., Çalık, G., Özdamar,T.H, 2002. Influence of pH conditions on metabolic regulations in serine alkaline protease production by Bacillus licheniformis , Enzyme and Microbial Technology, 31, 685-697 .
Çalık, P., Özçelik-Şenver, İ., Çalık, G., Özdamar,T.H., 2002. Separation of serine alkaline protease of B.licheniformis by ion-exchange from ultrafiltrated fermentation broth, Biochemical Engineering Journal, 12(3), 193-204.
Çalık, P., Bilir, E., Çalık, G., Özdamar,T.H, 2003. Bioreactor operation parameters as tools for metabolic regulations in fermentation processes : Influence of pH conditions. Chemical Engineering Science, 58(3), 759-766.
Çalık, P., Bayram, A., and Özdamar, T.H., 2003. Regulatory effects of alanine group amino acids on serine alkaline protease production by recombinant Bacillus licheniformis . Biotechnology and Applied Biochemistry, 37, 165-171.

CURRENT PROJECT
• Recombinant L-phenyl alanin production – TUBITAK- MISAG
• Recombinant a -interferon production- DPT-TUBITAK
• Recombinant protease production- DPT-TUBITAK
• Recombinant-human growth hormone production- TUBITAK- BAYG BDP

LABORATORIES
• Kinetics Laboratory
• Genetic Engineering Laboratory
• Research Laboratory