Bioprocess Research Group

PEOPLE
• Prof. Dr. Serpil TAKAÇ
• Res. Assist. Dr. A. Ezgi ÜNLÜ BÜYÜKTOPÇU
• Alper KARAKAYA (PhD Student)
• Didem DEĞİRMENBAŞI (MSc Student)
• Ceren ÜLGER (MSc Student)
• Azime ARIKAYA (MSc Student)

RESEARCH AREAS
Green Processes: Production/Separation
• Microbial lipid
• Microbial enzyme
• Pharmaceuticals
• Green solvents
• Biodegradation
• Enzymatic / chemical esterification / transesterification reactions
• Kinetics of enzymatic and microbial reactions
• Enzymatic resolution of racemic mixtures

 Current Projects
• 
Food Waste Valorisation for Sustainable Chemicals, Materials & Fuels (EUBis), COST Action TD1203 (2013-2016).

SELECTED PUBLICATIONS
• Bozkoyunlu, G, Takaç S., 2014. Parameters and kinetics of olive mill wastewater dephenolisation by immobilised Rhodotorulaglutiniscells, Environmental Technology, 35(24):3074-81.
• Karakaya, A., Bozkoyunlu, G., Laleli,Y., Takaç,S., 2103.Development of pH-adjustment based perational strategy to increase total phenol removal rate in biodegradation of olive mill wastewater by Rhodotorulaglutinis,  Desalination and Water Treatment, 52; 37-39, 7277-7281
• Karakaya, A., Laleli,Y., Takaç,S., 2012. Development of process conditions for biodegradation of raw olive mill wastewater by Rhodotorulaglutinis, International Biodeterioration& Biodegradation, 75, 75- 82.
• Ünlü,A.E., Takaç,S., 2012. Investigation of the Simultaneous Production of Superoxidedismutase and Catalase Enzymes from Rhodotorulaglutinis under Different Culture Conditions, Artificial Cells, Blood Substitutes, and Biotechnology, 40 (5,) 338-344.
• Tekin,N., ColeriCihan A., Takac,S., Yagci, C., Tunc,K., Cokmus,C., 2012. Characterization of an extremely stable alkaline protease from Bacillus cohnii APT5, Turkish Journal of Biology, 36, 430-44.
• Arslan, Y., Takaç, S., Eken-Saraçoğlu, N., 2012. Kinetic Study of Hemicellulosic Sugar Production from Hazelnut Shells, Chemical Engineering Journal, 185– 186, 23– 28.
• Takaç,S., Ünlü,A.E., Erdem,B., 2010. Oxygen Transfer Strategy Modulates the Productions of Lipase and Esterase Enzymes by Candida rugosa, Journal of Molecular Catalysis B: Ezymatic, 64, 150-154.
• Takaç, S., Şengel, B.Ş., 2010. Extracellular Lipolytic Enzyme Activity of a Newly Isolated Debaryomyceshansenii, Preparative Biochemistry & Biotechnology, 40, 28-37.
• Takaç, S., Karakaya, A., 2009. Recovery of Phenolic Antioxidants from Olive Mill Wastewater, Recent Patents on Chemical Engineering, 2(3), 230-237.
• Takaç, S., Erdem, B., Ünlü, A.E., 2009. Impact of Inoculation Strategy on the Progress of Candida rugosa Cultivation, Artificial Cells, Blood Substitutes, and Biotechnology, 37 (3) 130-137.
• Takaç, S., Erdem, B. 2009. Media Formulation Using Complex Organic Nutrients for the Improved Activity, Productivity and Yield of Candida rugosa Lipase and Esterase Enzymes Preparative Biochemistry & Biotechnology, 39 (3), 323-341.
• Takaç,S., Ünlü,A.E., 2009. Effects of Alcohol and Buffer Treatments on the Activity and Enantioselectivity of Candida rugosa lipase, Preparative Biochemistry & Biotechnology, 39: 124-141
• Takaç,S., Marul,B., 2008. Effects of Lipidic Carbon Sources on the Extracellular Lipolytic Activity of a Newly Isolated Bacillus subtilis, Journal of Industrial Microbiology & Biotechnology, 35: 1019-1025.
• Salgın,S., Takaç,S., 2007. Effect of Additives on the Activity and Enantioselectivity of Candida rugosa Lipase in Biphasic Medium, Chemical Engineering & Technology, 30 (12), 1739-1740.
• Ertuğrul,S., Dönmez,G., Takaç,S., 2007. Isolation of Lipase Producing Bacterial Strain from Olive Mill Wastewater and Improving its Enzyme Activity, Journal of Hazardous Materials, 149, 720-724.
• Salgın,U., Salgın,S., Takaç,S., 2007. The Enantioselective Hydrolysis of Racemic Naproxen Methyl Ester in Supercritical CO2 using Candida rugosa Lipase, Journal of Supercritical Fluids, 43(2), 310-316. 
Takaç,S., Mutlu,D., 2007. Biphasic Medium Conditions for the Enantioselective Production of Naproxen by Candida rugosaLipase, Applied Biochemistry and Biotechnology, 141 (1), 15-26.
• Takaç,S., Bakkal,M., 2007. Impressive Effect of Immobilization Conditions on the Catalytic Activity and Enantioselectivity ofCandida rugosa Lipase Toward S-Naproxen Production, Process Biochemistry, 42, 1021-1027.
Salgın, S., Takaç, S., Özdamar, T.H., 2006. Effect of Ionic Environments on the Adsorption and Diffusion Characteristics of Serine Alkaline Protease Enzyme in Polyethersulfone Ultrafiltration Membranes, Journal of Colloid and Interface Science, 299, 806-814.
Salgın,S., Takaç, S., Özdamar,T.H., 2006. Adsorption of bovine serum albumin on polyether sulfone ultrafiltration membranes: Determination of interfacial interaction energy and effective diffusion coefficient, Journal of Membrane Science, 278, 251-260
Salgın,S., Takaç,S., Özdamar,T.H., 2005. A Parametric Study on Protein-Membrane-Ionic Environment Interactions for Membrane Fouling, Separation Science and Technology, 40 (6), 1191-1212.
Boyacı,F.G., Takaç,S., Özdamar,T.H., 2005. Nucleophile Influence on the Complex Reaction Network of 2-Isopropylnaphthalene Hydroperoxide Decomposition, Chemical Engineering and Processing, 44, 1197-1206.
Takaç,S., San,B.,F.G., Kavdır,E., 2005. Effect of Reaction Conditions on the Product Distribution in the Liquid-Phase Acid-Catalysed Etherification of 2-Naphthol with Methanol, Reaction Kinetics and Catalysis Letters, 85(2), 291-298.

LABORATORY FACILITIES
High Pressure Liquid Chromotography;  Gas Chromotography; Bioreactors; UV-VIS Spectrophotometer; Laminar Flow; Sterilizator; Incubator Shakers; Deep Freeze;  Rotary Evaporator; Centrifuge; Refrigerated Circulator; Magnetic Stirrer; pHmeter; Analytical Balance